Mac and Cheese Meatloaf Casserole

Total Time: 1 hour 20 minutes
Prep Time: 25 minutes
Cook Time: 55 minutes
Difficulty Level: Medium
Servings: 6–8

Introduction

Imagine combining two ultimate comfort foods—creamy mac and cheese and juicy, flavorful meatloaf—into a single, indulgent casserole. This Mac and Cheese Meatloaf Casserole is the kind of all-in-one dish that’s guaranteed to please everyone at the table.

This recipe features a base layer of savory meatloaf made with a blend of beef, breadcrumbs, and seasoning, topped with a thick, creamy homemade mac and cheese, and finished with a golden crust of baked cheese and breadcrumbs. Whether you’re feeding a crowd or just want delicious leftovers for days, this dish has got you covered.

It’s hearty, satisfying, and hits all the right notes of rich, cheesy, meaty goodness. Perfect for Sunday dinners, potlucks, or even weeknight meals when you want something indulgent.

Ingredients

For the Meatloaf Layer:

• 1 ½ lbs ground beef (80/20 recommended)

• 1 egg

• 1 small onion, finely chopped

• 2 cloves garlic, minced

• ¾ cup breadcrumbs (panko or regular)

• 2 tablespoons ketchup

• 1 tablespoon Worcestershire sauce

• 1 teaspoon salt

• ½ teaspoon black pepper

• 1 teaspoon Italian seasoning or dried oregano

For the Mac and Cheese:

• 12 oz elbow macaroni or small pasta of choice

• 3 tablespoons butter

• 3 tablespoons all-purpose flour

• 2 cups whole milk (warm)

• 1 cup heavy cream

• 2 ½ cups sharp cheddar cheese, shredded

• 1 cup mozzarella cheese, shredded

• ½ teaspoon mustard powder (optional)

• Salt and pepper to taste

Topping (Optional but Recommended):

• ½ cup panko breadcrumbs

• ½ cup shredded cheddar

• 1 tablespoon butter, melted

• Chopped parsley (for garnish)

Kitchen Tools Needed

• Large mixing bowl

• Medium saucepan

• 9×13” baking dish or deep casserole dish

• Skillet or sauté pan

• Whisk

• Spatula or wooden spoon

• Cheese grater (if using block cheese)

• Measuring cups and spoons

Preparation Steps

Step 1: Preheat Oven

Preheat your oven to 375°F (190°C). Lightly grease a 9×13” baking dish or line with parchment paper for easier cleanup.

Step 2: Make the Meatloaf Base

1. In a large mixing bowl, combine ground beef, egg, breadcrumbs, onion, garlic, ketchup, Worcestershire sauce, salt, pepper, and seasoning.

2. Mix until just combined. Do not overmix, or the meat may become dense.

3. Press the meat mixture evenly into the bottom of your prepared baking dish. This will act as the “crust” of the casserole.

4. Bake for 20–25 minutes while you prepare the mac and cheese layer.

Step 3: Cook the Pasta

While the meatloaf is baking:

1. Boil a large pot of salted water.

2. Add macaroni and cook until just al dente (about 1–2 minutes less than package instructions). Drain and set aside.

Step 4: Make the Cheese Sauce

1. In a saucepan over medium heat, melt 3 tablespoons of butter.

2. Whisk in the flour and cook for 1–2 minutes until lightly golden and bubbling (this forms a roux).

3. Slowly whisk in warm milk and cream. Stir constantly until the mixture thickens (about 5–7 minutes).

4. Add cheddar, mozzarella, mustard powder, salt, and pepper. Stir until cheese is melted and sauce is smooth.

5. Combine the cooked pasta with the cheese sauce and stir well to coat.

Step 5: Assemble the Casserole

1. Remove the meatloaf base from the oven.

2. Drain off any excess grease (optional but recommended).

3. Spoon the mac and cheese mixture on top of the meatloaf layer, spreading evenly.

4. If using the topping, mix panko, cheddar, and melted butter in a bowl and sprinkle evenly over the mac and cheese.

Step 6: Bake the Casserole

Return the casserole to the oven and bake uncovered for 20–25 more minutes, or until the top is golden and bubbly.

Optional: Broil for 2–3 minutes at the end for a crispy, browned top.

Step 7: Rest and Serve

Let the casserole rest for 10 minutes before slicing. Garnish with chopped parsley for a fresh touch.

Tips for Best Results

• Use quality cheese: Grating your own cheese gives better melt and flavor than pre-shredded.

• Don’t overcook the pasta: It will continue to cook in the oven, so undercook it slightly.

• Drain meatloaf fat: If your beef is fatty, spoon off the excess grease after baking the meat layer.

• Add heat: Add chopped jalapeños or red pepper flakes for a spicy kick.

• Make it ahead: Assemble the casserole and refrigerate up to 24 hours ahead. Add 5–10 minutes to the final bake time.

Recipe Intensities

Nutrition Information (Approximate per serving, 1 of 8)

Values will vary based on ingredients used.

• Calories: 640 kcal

• Protein: 36g

• Fat: 38g

• Saturated Fat: 18g

• Carbohydrates: 38g

• Sugar: 4g

• Fiber: 2g

• Sodium: 750mg

• Cholesterol: 140mg

To lighten the dish:

• Use lean ground turkey or chicken.

• Substitute half-and-half or low-fat milk for the cream.

• Use reduced-fat cheese.

Why You’ll Love This Recipe

• Comfort food fusion: Two favorites in one!

• Hearty and filling: Perfect for big appetites and leftovers.

• Kid-friendly: Mac and cheese plus meat = guaranteed hit.

• Customizable: Swap pasta, meat, or seasonings easily.

• Make-ahead friendly: Prep in advance for stress-free meals.

Storage and Reheating

• Fridge: Store leftovers in an airtight container for up to 4 days.

• Freezer: Freeze in individual portions for up to 3 months. Thaw overnight in the fridge before reheating.

• Reheating: Microwave individual slices or reheat in the oven at 350°F until warmed through.

Serving Suggestions

Serve with:

• Steamed broccoli or green beans

• Garden salad with vinaigrette

• Garlic bread or dinner rolls

• Pickles or slaw for contrast

For drinks:

• A crisp IPA or amber ale

• Sparkling water with lemon

• Iced tea or cola for a casual dinner

Final Thoughts

The Mac and Cheese Meatloaf Casserole is the perfect dish when you want big flavors, creamy textures, and stick-to-your-ribs satisfaction. It’s a fusion of everything people love—tender, seasoned meat, cheesy pasta, and that comforting baked casserole vibe.

Whether you’re feeding a hungry family or just cooking for yourself with plans for leftovers, this casserole is a win. It’s bold, it’s cheesy, it’s filling—and it’s guaranteed to become a regular in your recipe rotation.